May 28, 2022
Live Well Club

Arthritis is a painful condition that affects many seniors, both in Australia and worldwide.

Currently, there are close to a thousand scientific articles on turmeric and its analogues, which have been used successfully in the treatment of arthritis. For some, however, there is difficulty in the absorption of turmeric. Thankfully, there are methods to address this.

Golden Paste

Golden Paste (recipe found here) is the simplest method to aid in the absorption of turmeric in the treatment of your arthritis. This can be incorporated into your food and consumed at the rate of half to one teaspoon per serve.

Healthy Gut

For your body to effectively metabolise the turmeric, you will need a healthy adaptive gut biota, which is achieved by high-fibre natural vegetable intake, eliminating all added sugars and processed foods that have sugar additives. This includes biscuits, cakes, desserts, sauces, and snack foods.

Note, if consumption of turmeric causes diarrhoea, this is indicative of a poor microflora gut population. Diet change is needed to build a healthy adaptive population of microbes in the gastrointestinal system.


Studies have shown the curcumin could effectively alleviate gouty arthritis through inhibiting involved inflammatory mediators. This suggests it to be a promising active ingredient for the prevention and treatment of gouty arthritis.

Curcumin has been found to be a preventive measure to avoid/manage tooth root infection (periodontitis), as well as work as a natural immunosuppressant for rheumatoid arthritis.

Periodontitis is mainly caused by the bacteria Porphyromonas gingivalis forming biofilm and leading to tooth decay. This is a major public health issue and a risk factor for the development of rheumatoid arthritis. Curcumin appears to have efficient anti-bacterial activity against P. Gingivalis infection, and biofilm formation.


In addition to antibacterial, antioxidant, and anti-inflammatory action, curcumin exerts unique immunosuppressant properties.

Curcumin is a natural product for the management of both periodontitis and rheumatoid arthritis-related autoreactivity.

When it comes to your health, it is always best to speak with your GP before making any diet or exercise changes. In your next appointment, make sure to enquire about turmeric and how it may help you live a happier and healthier life.

Courtesy of Dr Doug –

The information and views contained in this article are those of the author and this publication has not sought to verify them. The contents of this article are not advice; they are general in nature and do not take into account your personal health or circumstances. You should seek professional healthcare advice before taking supplements, additives or anything that affects your health. Australian Over 50s Living & Lifestyle Guide.

1: Li X, Xu DQ, Sun DY, Zhang T, He X, Xiao DM. Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling. J Cell Biochem. 2018 Dec 28.doi: 10.1002/jcb.27969. [Epub ahead of print] PubMed PMID: 30592318.

These results indicated that curcumin could effectively ameliorate MSU crystal-induced gouty arthritis through NLRP3 inflammasome mediation via inhibiting NF-κB signaling both in vitro and in vivo, suggesting a promising active ingredient for the prevention and treatment of gouty arthritis. Curcumin was injected intraperitoneally though to shortcut any poor intestinal absorption.
2: Dai Q, Zhou D, Xu L, Song X. Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. Drug Des Devel Ther. 2018 Dec 3;12:4095-4105. doi: 10.2147/DDDT.S175763. eCollection 2018.
PubMed PMID: 30584274; PubMed Central PMCID: PMC6284537.

Our findings show that curcumin alleviates CIA-induced inflammation, synovial hyperplasia, and the other main features involved in the pathogenesis of CIA via the mTOR pathway. These results provide evidence for the anti-arthritic properties of curcumin and corroborate its potential use for the treatment of Reumatoid Arthritis. Dose of curcumin was 200mg/kg though, = 14gms for a human and also the rats were treated with rapamycin which is a standard treatment for RA.
Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. Wikipedia
3: Song X, Zhang M, Dai E, Luo Y. Molecular targets of curcumin in breast cancer (Review). Mol Med Rep. 2018 Nov 19. doi:.3892/mmr.2018.9665. [Epub ahead of print] PubMed PMID: 30483727.

Curcumin (diferuloylmethane), an orange yellow component of turmeric or curry powder, is a polyphenol natural product isolated from the rhizome of Curcuma longa.
For centuries, curcumin has been used in medicinal preparations and as a food colorant.
In recent years, extensive in vitro and in vivo studies have suggested that curcumin possesses activity against
cancer, viral infection, arthritis, amyloid aggregation, oxidation and inflammation.
Curcumin exerts anticancer effects primarily by activating apoptotic pathways in cancer cells and inhibiting pro cancer processes, including inflammation, angiogenesis and metastasis.
Curcumin targets numerous signaling pathways associated with cancer therapy, including pathways mediated by p53, Ras, phosphatidylinositol 3 kinase, protein kinase B, Wnt β catenin and mammalian target of rapamycin. Clinical studies have demonstrated that curcumin alone or combined with other drugs exhibits promising anticancer activity in patients with breast cancer without adverse effects. In the present review, the chemistry and bioavailability of curcumin and its molecular targets in breast cancer are discussed. Future research directions are discussed to further understand this promising natural product.
4: Sun Z, Wei T, Zhou X. Liposomes encapsulated dimethyl curcumin regulates dipeptidyl peptidase I activity, gelatinase release and cell cycle of spleen lymphocytes in-vivo to attenuate collagen induced arthritis in rats. Int Immunopharmacol. 2018 Dec;65:511-521. doi: 10.1016/j.intimp.2018.10.039. Epub 2018 Nov 5. PubMed PMID: 30408628.

Rheumatoid arthritis (RA) is an autoimmune disease and characterized by the excessive cell proliferation, abnormal cell cycle of lymphocytes and synovial cells.
The therapeutic effects of curcumin in active RA patients were reported, but limited by its insolubility and rapid systemic elimination.
Dimethyl curcumin (DiMC) is a metabolically stable analogue of curcum with anti-inflammatory property.
In this study, liposomes encapsulated dimethyl curcumin (Lipo-DiMC) was prepared to improve the bioavailability and metabolic-stability; collagen induced arthritis (CIA) rat model was employed to investigate the effects of Lipo-DiMC treatments during CIA progress.
Physical assessments and routine-blood-test were performed. Fresh spleen lymphocytes were isolated from normal, CIA and Lipo-DiMC-treated CIA rats; flow-cytometry for cell-cycle analysis, western-blotting for intracellular signal pathway protein expressions, gelatin-zymography for matrix-metalloproteases 2/9 (MMP-2/9) and GF-AFC for dipeptidyl-peptidase I (DPPI) activity assay.
Compared with untreated CIA rats, Lipo-DiMC treatments relieved paw-swellings, suppressed the increments of immunocytes numbers and inhibited DPPI and MMP-2/9 over-activity in blood.
Lipo-DiMC adjusted CIA-induced cell cycle dysfunction at G0/G1-phase and S-phase of spleen lymphocytes for CIA rats.
The intracellular expression-trends of P38, P21, Bcl-2, JNK-1 and DPPI of spleen lymphocytes were observed during CIA progress with and without Lipo-DiMC administrations.
Lipo-DiMC exhibited its therapeutic functions by attenuating CIA development in rats, associated with down-regulating CIA-induced lymphocytes numbers, inhibiting over-expressed of DPPI and MMP-2/9, and adjusting cell cycles.
These findings provide a new insight into the mechanism of Lipo-DiMC treatment in CIA rat model and suggest that Lipo-DiMC could be considered as a potential drug for RA treatment.
5: Tasneem S, Liu B, Li B, Choudhary MI, Wang W. Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents. Pharmacol Res. 2018 Nov 3;139:126-140. doi: 10.1016/j.phrs.2018.11.001. [Epub ahead of print] Review. PubMed PMID: 30395947.

Except for an essential step for the pathology of multiple diseases including atherosclerosis and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing novel approaches for pharmacological interventions.
Thus, molecular understanding of inflammation not only revealed the mechanisms of drug action and their biological targets but also has spawned innovative maneuvers to influence multifaceted biological systems, providing new prospects for drug designing and suggesting important new implications for existing clinical medicine.
Meanwhile, modulation of inflammation with the use of medicinal plants proposed an alternate to conventional therapeutic strategies for numerous ailments, particularly when suppression of inflammation is expected.
In modern literature, several species of medicinal plants have been shown substantial anti-inflammatory and immunomodulatory actions including inhibitory effects on suppression of cellular and humoral immunity, lymphocyte activation, and propagation of apoptosis.
Herein, we reviewed the molecular pharmacology of inflammation, chemical components and biological activities of medicinal plants such as, curcumin from Curcuma longa, and epigallocatechin-3-gallate from Camellia sinensis as well as their mechanism of action during inflammation at molecular level.
An extensive review of the literature and electronic databases was conducted, encompassing PubMed, GoogleScholar, ScienceDirect, medlineplus,,,,,,, and for assembling the information.
Additionally, data was attained from books, ethnopharmacological literature, and relevant publications for essential elements of molecular mechanisms, signal transduction networks, transcription factors, complement system, reactive species, and clinical trials are selected for substantial understanding of biochemistry, pathophysiology as well as clinical importance of medicinal plants during inflammatory diseases.

6: Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases. Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Review. PubMed PMID: 30319623; PubMed Central PMCID: PMC6170639.

Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases.
The inflammatory molecules and transcription factors, adhesion molecules, AP-1, chemokines, C-reactive protein (CRP), cyclooxygenase (COX)-2, interleukins (ILs), 5-lipooxygenase (5-LOX), matrix metalloproteinases (MMPs), nuclear factor (NF)-kB, signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor (TNF), and vascular endothelial growth factor (VEGF) are molecular links between inflammation and chronic diseases.
Thus, suppression of inflammatory molecules could be potential strategy for the prevention and therapy of chronic diseases.
The currently available drugs against chronic diseases are highly expensive, minimally effective and produce several side effects when taken for long period of time.
The focus of this review is to discuss the potential of nutraceuticals derived from “Mother Nature” such as apigenin, catechins, curcumin, ellagic acid, emodin, epigallocatechin gallate, escin, fisetin, flavopiridol, genistein, isoliquiritigenin, kaempferol, mangostin, morin, myricetin, naringenin, resveratrol, silymarin, vitexin, and xanthohumol in suppression of these inflammatory pathways.
Thus, these nutraceuticals offer potential in preventing or delaying the onset of chronic diseases. We provide evidence for the potential of these nutraceuticals from pre-clinical and clinical studies.
7: Attiq A, Jalil J, Husain K, Ahmad W. Raging the War Against Inflammation With Natural Products. Front Pharmacol. 2018 Sep 7;9:976. doi: 10.3389/fphar.2018.00976. eCollection 2018. Review. PubMed PMID: 30245627; PubMed Central PMCID: PMC6137277.

8: Henrotin Y, Mobasheri A. Natural Products for Promoting Joint Health and Managing Osteoarthritis. Curr Rheumatol Rep. 2018 Sep 19;20(11):72. doi: 10.1007/s11926-018-0782-9. Review. PubMed PMID: 30232562.

9: Dudics S, Langan D, Meka RR, Venkatesha SH, Berman BM, Che CT, Moudgil KD. Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome. Int J Mol Sci. 2018 Aug 24;19(9). pii: E2508. doi: 10.3390/ijms19092508. Review. PubMed PMID: 30149545; PubMed Central PMCID: PMC6164747.

10: Wang J, Wang X, Cao Y, Huang T, Song DX, Tao HR. Therapeutic potential of hyaluronic acid/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in vitro evaluation in chondrocytes. Int J Mol Med. 2018 Nov;42(5):2604-2614. doi: 10.3892/ijmm.2018.3817. Epub 2018 Aug 9. PubMed PMID:
30106112; PubMed Central PMCID: PMC6192775.

11: Kurien BT, Thomas R, Payne A, Scofield RH. Heat/Pressure Treatment with Detergents Significantly Increases Curcumin Solubility and Stability: Its Use as an  Environment-Friendly Protein Gel Stain. Methods Mol Biol. 2018;1853:237-246. doi: 10.1007/978-1-4939-8745-0_27. PubMed PMID: 30097949.

12: Kurien BT, Dorri Y, Scofield RH. Curcumin/Turmeric as an Environment-Friendly Protein Gel Stain. Methods Mol Biol. 2018;1853:121-131. doi: 10.1007/978-1-4939-8745-0_15. PubMed PMID: 30097937.

13: Khayyal MT, El-Hazek RM, El-Sabbagh WA, Frank J, Behnam D, Abdel-Tawab M. Micellar solubilisation enhances the antiinflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis. Nutrition. 2018 Oct;54:189-196. doi: 10.1016/j.nut.2018.03.055. Epub 2018 Apr 23. PubMed PMID:

14: Asteriou E, Gkoutzourelas A, Mavropoulos A, Katsiari C, Sakkas LI, Bogdanos DP. Curcumin for the Management of Periodontitis and Early ACPA-Positive Rheumatoid Arthritis: Killing Two Birds with One Stone. Nutrients. 2018 Jul 16;10(7). pii: E908. doi: 10.3390/nu10070908. Review. PubMed PMID: 30012973;
PubMed Central PMCID: PMC6073415.

15: Fan Z, Li J, Liu J, Jiao H, Liu B. Anti-Inflammation and Joint Lubrication Dual Effects of a Novel Hyaluronic Acid/Curcumin Nanomicelle Improve the Efficacy of Rheumatoid Arthritis Therapy. ACS Appl Mater Interfaces. 2018 Jul 18;10(28):23595-23604. doi: 10.1021/acsami.8b06236. Epub 2018 Jul 2. PubMed PMID: 29920067.

16: Pagano E, Romano B, Izzo AA, Borrelli F. The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews. Pharmacol Res. 2018 Aug;134:79-91. doi: 10.1016/j.phrs.2018.06.007. Epub 2018 Jun 8. Review. PubMed PMID: 29890252.

17: Chen L, Lu Y, Zhao L, Hu L, Qiu Q, Zhang Z, Li M, Hong G, Wu B, Zhao G, Lu Z. Curcumin attenuates sepsis-induced acute organ dysfunction by preventing inflammation and enhancing the suppressive function of Tregs. Int Immunopharmacol. 2018 Aug;61:1-7. doi: 10.1016/j.intimp.2018.04.041. Epub 2018 May 17. PubMed PMID: 29778842.

18: Mobasheri A, Henrotin Y. Comment on: Efficacy of Curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis. Semin Arthritis Rheum. 2018 Apr 11. pii: S0049-0172(18)30173-2. doi: 10.1016/j.semarthrit.2018.04.002. [Epub ahead of print] PubMed PMID: 29735172.

19: Bannuru RR, Osani MC, Al-Eid F, Wang C. Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis. Semin Arthritis Rheum. 2018 Dec;48(3):416-429. doi: 10.1016/j.semarthrit.2018.03.001. Epub 2018 Mar 10. PubMed PMID: 29622343; PubMed Central PMCID: PMC6131088.

20: Sundar Dhilip Kumar S, Houreld NN, Abrahamse H. Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases. Molecules. 2018 Apr 5;23(4). pii: E835. doi: 10.3390/molecules23040835. Review. PubMed PMID: 29621160; PubMed Central PMCID: PMC6017430.

21: Cavaleri F. Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin. Int J Inflam. 2018 Jan 15;2018:5023429. doi: 10.1155/2018/5023429. eCollection 2018. Review. PubMed PMID: 29568482; PubMed Central PMCID: PMC5820622.

22: Belcaro G, Dugall M, Luzzi R, Hosoi M, Ledda A, Feragalli B, Hu S, Ganguly A, Eggenhoffner R, Corti A, Giacomelli L. Phytoproflex®: supplementary management of osteoarthrosis: a supplement registry. Minerva Med. 2018 Apr;109(2):88-94. doi: 10.23736/S0026-4806.17.05460-X. PubMed PMID: 29534559.

23: Liu X, Eyles J, McLachlan AJ, Mobasheri A. Which supplements can I recommend to my osteoarthritis patients? Rheumatology (Oxford). 2018 May 1;57(suppl_4):iv75-iv87. doi: 10.1093/rheumatology/key005. Review. PubMed PMID: 29506080.

24: Mantzorou M, Pavlidou E, Vasios G, Tsagalioti E, Giaginis C. Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data. Phytother Res. 2018 Jun;32(6):957-975. doi: 10.1002/ptr.6037. Epub 2018 Feb 22. Review. PubMed PMID: 29468820.

25: Ghosh SS, He H, Wang J, Gehr TW, Ghosh S. Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects. Tissue Barriers. 2018 Jan 2;6(1):e1425085. doi: 10.1080/21688370.2018.1425085. Epub 2018 Feb 8. Review. PubMed PMID: 29420166; PubMed Central PMCID: PMC5823546.

26: Reddy PH, Manczak M, Yin X, Grady MC, Mitchell A, Tonk S, Kuruva CS, Bhatti JS, Kandimalla R, Vijayan M, Kumar S, Wang R, Pradeepkiran JA, Ogunmokun G, Thamarai K, Quesada K, Boles A, Reddy AP. Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease. J Alzheimers Dis.
2018;61(3):843-866. doi: 10.3233/JAD-170512. PubMed PMID: 29332042; PubMed Central PMCID: PMC5796761.

27: Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A, Narimanyan M, Hovhannisyan A. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018 Jan 9;18(1):7. doi: 10.1186/s12906-017-2062-z. PubMed PMID: 29316908; PubMed Central PMCID: PMC5761198.

28: Dou Y, Luo J, Wu X, Wei Z, Tong B, Yu J, Wang T, Zhang X, Yang Y, Yuan X, Zhao P, Xia Y, Hu H, Dai Y. Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”. J Neuroinflammation. 2018 Jan 6;15(1):6. doi: 10.1186/s12974-017-1047-7. PubMed PMID: 29306322; PubMed Central PMCID: PMC5756354.

29: Li XS, Chen H, Zhen P, Li SS, Zhou SH, Tian Q, Shi J, He XL, Liu J. [JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis]. Zhongguo Gu Shang. 2016 Dec 25;29(12):1104-1109. doi: 10.3969/j.issn.1003-0034.2016.12.008. Chinese. PubMed PMID: 29292884.

30: Comblain F, Barthélémy N, Lefèbvre M, Schwartz C, Lesponne I, Serisier S, Feugier A, Balligand M, Henrotin Y. A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner’s dogs with
osteoarthritis. BMC Vet Res. 2017 Dec 20;13(1):395. doi: 10.1186/s12917-017-1317-8. PubMed PMID: 29262825; PubMed Central PMCID: PMC5738810.

31: Aborehab NM, El Bishbishy MH, Refaiy A, Waly NE. A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis. BMC Complement Altern Med. 2017 Nov 22;17(1):495. doi: 10.1186/s12906-017-2002-y. PubMed PMID: 29166937; PubMed Central PMCID: PMC5700518.

32: Hewlings SJ, Kalman DS. Curcumin: A Review of Its’ Effects on Human Health. Foods. 2017 Oct 22;6(10). pii: E92. doi: 10.3390/foods6100092. Review. PubMed PMID: 29065496; PubMed Central PMCID: PMC5664031.

33: Gera M, Sharma N, Ghosh M, Huynh DL, Lee SJ, Min T, Kwon T, Jeong DK. Nanoformulations of curcumin: an emerging paradigm for improved remedial application. Oncotarget. 2017 Jul 11;8(39):66680-66698. doi: 10.18632/oncotarget.19164. eCollection 2017 Sep 12. Review. PubMed PMID: 29029547; PubMed Central PMCID: PMC5630447.

34: Sun Y, Liu W, Zhang H, Li H, Liu J, Zhang F, Jiang T, Jiang S. Curcumin Prevents Osteoarthritis by Inhibiting the Activation of Inflammasome NLRP3. J Interferon Cytokine Res. 2017 Oct;37(10):449-455. doi: 10.1089/jir.2017.0069. PubMed PMID: 29028430.

35: Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018 Feb;52(3):167-175. doi: 10.1136/bjsports-2016-097333. Epub 2017 Oct 10. Review. PubMed PMID: 29018060.

36: Lee G, Chung HS, Lee K, Lee H, Kim M, Bae H. Curcumin attenuates the scurfy-induced immune disorder, a model of IPEX syndrome, with inhibiting Th1/Th2/Th17 responses in mice. Phytomedicine. 2017 Sep 15;33:1-6. doi: 10.1016/j.phymed.2017.01.008. Epub 2017 Jan 19. PubMed PMID: 28887914.

37: Oliviero F, Scanu A, Zamudio-Cuevas Y, Punzi L, Spinella P. Anti-inflammatory effects of polyphenols in arthritis. J Sci Food Agric. 2018 Mar;98(5):1653-1659. doi: 10.1002/jsfa.8664. Epub 2017 Oct 9. Review. PubMed PMID: 28886220.

38: Vaughn AR, Haas KN, Burney W, Andersen E, Clark AK, Crawford R, Sivamani RK. Potential Role of Curcumin Against Biofilm-Producing Organisms on the Skin: A Review. Phytother Res. 2017 Dec;31(12):1807-1816. doi: 10.1002/ptr.5912. Epub 2017 Sep 7. Review. PubMed PMID: 28884496.

39: Amalraj A, Varma K, Jacob J, Divya C, Kunnumakkara AB, Stohs SJ, Gopi S. A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study. J Med Food. 2017 Oct;20(10):1022-1030. doi: 10.1089/jmf.2017.3930. Epub 2017 Aug 29. PubMed PMID: 28850308.

40: Schell J, Scofield RH, Barrett JR, Kurien BT, Betts N, Lyons TJ, Zhao YD, Basu A. Strawberries Improve Pain and Inflammation in Obese Adults with Radiographic Evidence of Knee Osteoarthritis. Nutrients. 2017 Aug 28;9(9). pii: E949. doi: 10.3390/nu9090949. PubMed PMID: 28846633; PubMed Central PMCID:

41: Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A. Immune modulation by curcumin: The role of interleukin-10. Crit Rev Food Sci Nutr. 2017 Aug 11:1-13. doi: 10.1080/10408398.2017.1358139. [Epub ahead of print] PubMed PMID: 28799796.

42: Shehzad A, Qureshi M, Anwar MN, Lee YS. Multifunctional Curcumin Mediate Multitherapeutic Effects. J Food Sci. 2017 Sep;82(9):2006-2015. doi: 10.1111/1750-3841.13793. Epub 2017 Aug 3. Review. PubMed PMID: 28771714.

43: Fadus MC, Lau C, Bikhchandani J, Lynch HT. Curcumin: An age-old anti-inflammatory and anti-neoplastic agent. J Tradit Complement Med. 2016 Sep 9;7(3):339-346. doi: 10.1016/j.jtcme.2016.08.002. eCollection 2017 Jul. Review. PubMed PMID: 28725630; PubMed Central PMCID: PMC5506636.

44: Zdrojewicz Z, Szyca M, Popowicz E, Michalik T, Åšmieszniak B. [Turmeric – not only spice]. Pol Merkur Lekarski. 2017 Jun 23;42(252):227-230. Review. Polish. PubMed PMID: 28662006.

45: McCubrey JA, Lertpiriyapong K, Steelman LS, Abrams SL, Cocco L, Ratti S, Martelli AM, Candido S, Libra M, Montalto G, Cervello M, Gizak A, Rakus D. Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases. Adv Biol Regul. 2017 Aug;65:77-88. doi: 10.1016/j.jbior.2017.05.005. Epub 2017 May 26. Review. PubMed PMID: 28579298.

46: Kurien BT, Matsumoto H, Scofield RH. Nutraceutical Value of Pure Curcumin. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S161-S163. doi: 10.4103/0973-1296.203988. Epub 2017 Apr 7. PubMed PMID: 28479742; PubMed Central PMCID: PMC5407110.

47: Onakpoya IJ, Spencer EA, Perera R, Heneghan CJ. Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials. Int J Rheum Dis. 2017 Apr;20(4):420-433. doi: 10.1111/1756-185X.13069. Epub 2017 May 4. Review. PubMed PMID: 28470851.

48: Chen L, Liu T, Wang Q, Liu J. Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo. BMC Complement Altern Med. 2017 Apr 27;17(1):233. doi: 10.1186/s12906-017-1739-7. PubMed PMID: 28449676; PubMed Central PMCID: PMC5408375.

49: Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review. J Tradit Complement Med. 2016 Jun 15;7(2):205-233. doi: 10.1016/j.jtcme.2016.05.005. eCollection 2017 Apr. Review. PubMed PMID: 28417091; PubMed Central PMCID: PMC5388087.

50: Fu M, Chen L, Zhang L, Yu X, Yang Q. Cyclocurcumin, a curcumin derivative, exhibits immune-modulating ability and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. Int J Mol Med. 2017 May;39(5):1164-1172. doi: 10.3892/ijmm.2017.2926. Epub 2017 Mar 20. PubMed PMID: 28339004; PubMed Central PMCID: PMC5403524.

51: Sumeet G, Rachna K, Samrat C, Ipshita C, Vikas J, Manu S. Anti Inflammatory and Anti Arthritic Activity of Different Milk Based Formulation of Curcumin in Rat Model. Curr Drug Deliv. 2018 Feb 14;15(2):205-214. doi: 10.2174/1567201814666170320142851. PubMed PMID: 28322165.

52: Sahu D, Sharma S, Singla RK, Panda AK. Antioxidant activity and protective effect of suramin against oxidative stress in collagen induced arthritis. Eur J Pharm Sci. 2017 Apr 1;101:125-139. doi: 10.1016/j.ejps.2017.02.013. Epub 2017 Feb 9. PubMed PMID: 28189815.

53: Kinger M, Kumar S, Kumar V. Some Important Dietary Polyphenolic Compounds: An Anti-inflammatory and Immunoregulatory Perspective. Mini Rev Med Chem. 2018;18(15):1270-1282. doi: 10.2174/1389557517666170208143410. Review. PubMed PMID: 28183265.

54: Liu J, He X, Zhen P, Zhou S, Li X. [Inflammatory cytokines and oxidative stress markers in the inhibition of osteoarthritis by curcumin]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 May 25;45(5):461-468. Chinese. PubMed PMID: 28087905.

55: Paolino D, Vero A, Cosco D, Pecora TM, Cianciolo S, Fresta M, Pignatello R. Improvement of Oral Bioavailability of Curcumin upon Microencapsulation with Methacrylic Copolymers. Front Pharmacol. 2016 Dec 21;7:485. doi: 10.3389/fphar.2016.00485. eCollection 2016. PubMed PMID: 28066239; PubMed Central
PMCID: PMC5174134.

56: Rahman M, Beg S, Verma A, Al Abbasi FA, Anwar F, Saini S, Akhter S, Kumar V. Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery. J Pharm Pharmacol. 2017 Jan;69(1):1-14. doi: 10.1111/jphp.12661. Epub 2016 Oct 24. Review. PubMed PMID: 27774648.

57: Karimian MS, Pirro M, Majeed M, Sahebkar A. Curcumin as a natural regulator of monocyte chemoattractant protein-1. Cytokine Growth Factor Rev. 2017 Feb;33:55-63. doi: 10.1016/j.cytogfr.2016.10.001. Epub 2016 Oct 8. Review. PubMed PMID: 27743775.

58: Chin KY. The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des Devel Ther. 2016 Sep 20;10:3029-3042. eCollection 2016. Review. PubMed PMID: 27703331; PubMed Central PMCID: PMC5036591.

59: Shang W, Zhao LJ, Dong XL, Zhao ZM, Li J, Zhang BB, Cai H. Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways. Mol Med Rep. 2016 Oct;14(4):3620-6. doi: 10.3892/mmr.2016.5674. Epub 2016 Aug 25. PubMed PMID: 27572279; PubMed Central PMCID: PMC5042742.

60: Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016 Aug;19(8):717-29. doi: 10.1089/jmf.2016.3705. Review. PubMed PMID: 27533649; PubMed Central PMCID:

61: Rahimi HR, Nedaeinia R, Sepehri Shamloo A, Nikdoust S, Kazemi Oskuee R. Novel delivery system for natural products: Nano-curcumin formulations. Avicenna J Phytomed. 2016 Jul-Aug;6(4):383-98. Review. PubMed PMID: 27516979; PubMed Central PMCID: PMC4967834.

62: Kloesch B, Gober L, Loebsch S, Vcelar B, Helson L, Steiner G. In Vitro Study of a Liposomal Curcumin Formulation (Lipocurcâ„¢): Toxicity and Biological Activity in Synovial Fibroblasts and Macrophages. In Vivo. 2016 Jul-Aug;30(4):413-9. PubMed PMID: 27381602.

63: Zhang Z, Leong DJ, Xu L, He Z, Wang A, Navati M, Kim SJ, Hirsh DM, Hardin JA, Cobelli NJ, Friedman JM, Sun HB. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther. 2016 Jun 3;18(1):128. doi: 10.1186/s13075-016-1025-y. PubMed PMID: 27260322; PubMed Central PMCID: PMC4891896.

64: Mande PP, Bachhav SS, Devarajan PV. Solid Dispersion of Curcumin as Polymeric Films for Bioenhancement and Improved Therapy of Rheumatoid Arthritis. Pharm Res. 2016 Aug;33(8):1972-87. doi: 10.1007/s11095-016-1934-0. Epub 2016 May 31. PubMed PMID: 27245466.

65: Jeengar MK, Shrivastava S, Mouli Veeravalli SC, Naidu VG, Sistla R. Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil. Nutrition. 2016 Sep;32(9):955-64. doi:
10.1016/j.nut.2016.02.009. Epub 2016 Mar 8. PubMed PMID: 27178879.

66: Allijn IE, Schiffelers RM, Storm G. Comparison of pharmaceutical nanoformulations for curcumin: Enhancement of aqueous solubility and carrier retention. Int J Pharm. 2016 Jun 15;506(1-2):407-13. doi: 10.1016/j.ijpharm.2016.04.070. Epub 2016 Apr 29. PubMed PMID: 27139142.

67: Jeengar MK, Rompicharla SV, Shrivastava S, Chella N, Shastri NR, Naidu VG, Sistla R. Emu oil-based nano-emulgel for topical delivery of curcumin. Int J Pharm. 2016 Jun 15;506(1-2):222-36. doi: 10.1016/j.ijpharm.2016.04.052. Epub 2016 Apr 22. PubMed PMID: 27109049.

68: Wang WH, Chuang HY, Chen CH, Chen WK, Hwang JJ. Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment. Biomed Pharmacother. 2016 Apr;79:231-40. doi: 10.1016/j.biopha.2016.02.010. Epub 2016 Mar 11. PubMed PMID: 27044833.

69: Sterzi S, Giordani L, Morrone M, Lena E, Magrone G, Scarpini C, Milighetti S, Pellicciari L, Bravi M, Panni I, Ljoka C, Bressi F, Foti C. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study. Eur J Phys Rehabil Med. 2016 Jun;52(3):321-30. Epub 2016 Mar 3. PubMed PMID: 26937646.

70: Fattori V, Amaral FA, Verri WA Jr. Neutrophils and arthritis: Role in disease and pharmacological perspectives. Pharmacol Res. 2016 Oct;112:84-98. doi: 10.1016/j.phrs.2016.01.027. Epub 2016 Jan 27. Review. PubMed PMID: 26826283.

71: TenBroek EM, Yunker L, Nies MF, Bendele AM. Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat. Arthritis Res Ther. 2016 Jan 21;18:24. doi: 10.1186/s13075-016-0921-5. PubMed PMID: 26794830; PubMed Central PMCID: PMC4721142.

72: Yimam M, Lee YC, Moore B, Jiao P, Hong M, Nam JB, Kim MR, Hyun EJ, Chu M, Brownell L, Jia Q. Analgesic and anti-inflammatory effects of UP1304, a botanical composite containing standardized extracts of Curcuma longa and Morus alba. J Integr Med. 2016 Jan;14(1):60-8. doi: 10.1016/S2095-4964(16)60231-5. PubMed PMID: 26778230.

73: Grover AK, Samson SE. Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality. Nutr J. 2016 Jan 5;15:1. doi: 10.1186/s12937-015-0115-z. Review. PubMed PMID: 26728196; PubMed Central PMCID: PMC4700773.

74: Ahn JK, Kim S, Hwang J, Kim J, Lee YS, Koh EM, Kim KH, Cha HS. Metabolomic Elucidation of the Effects of Curcumin on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. PLoS One. 2015 Dec 30;10(12):e0145539. doi: 10.1371/journal.pone.0145539. eCollection 2015. PubMed PMID: 26716989; PubMed Central PMCID: PMC4696817.

75: Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, DE Lillo A, Laino L, Lo Muzio L. Biological and therapeutic activities, and anticancer properties of curcumin. Exp Ther Med. 2015 Nov;10(5):1615-1623. Epub 2015 Sep 17. PubMed PMID: 26640527; PubMed Central PMCID: PMC4665301.

76: von Rhein C, Weidner T, Henß L, Martin J, Weber C, Sliva K, Schnierle BS. Curcumin and Boswellia serrata gum resin extract inhibit chikungunya and vesicular stomatitis virus infections in vitro. Antiviral Res. 2016 Jan;125:51-7. doi: 10.1016/j.antiviral.2015.11.007. Epub 2015 Dec 2. PubMed PMID: 26611396.

77: Sankrityayan H, Majumdar AS. Curcumin and folic acid abrogated methotrexate induced vascular endothelial dysfunction. Can J Physiol Pharmacol. 2016 Jan;94(1):89-96. doi: 10.1139/cjpp-2015-0156. Epub 2015 Nov 16. PubMed PMID: 26571019.

78: Kurien BT, Harris VM, Quadri SM, Coutinho-de Souza P, Cavett J, Moyer A, Ittiq B, Metcalf A, Ramji HF, Truong D, Kumar R, Koelsch KA, Centola M, Payne A, Danda D, Scofield RH. Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment. Lupus Sci Med. 2015 Sep 8;2(1):e000114. doi: 10.1136/lupus-2015-000114. eCollection 2015. PubMed PMID: 26380101; PubMed Central PMCID: PMC4567741.

79: Zheng Z, Sun Y, Liu Z, Zhang M, Li C, Cai H. The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Des Devel Ther. 2015 Aug 27;9:4931-42. doi: 10.2147/DDDT.S90147. eCollection 2015. PubMed PMID: 26345159; PubMed Central PMCID: PMC4555965.

80: Shin HS, See HJ, Jung SY, Choi DW, Kwon DA, Bae MJ, Sung KS, Shon DH. Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy. J Ethnopharmacol. 2015 Dec 4;175:21-9. doi: 10.1016/j.jep.2015.08.038. Epub 2015 Sep 2. PubMed PMID: 26342520.

81: Peddada KV, Peddada KV, Shukla SK, Mishra A, Verma V. Role of Curcumin in Common Musculoskeletal Disorders: a Review of Current Laboratory, Translational, and Clinical Data. Orthop Surg. 2015 Aug;7(3):222-31. doi: 10.1111/os.12183. Review. PubMed PMID: 26311096.

82: Kurien BT, Danda D, Scofield RH. Therapeutic potential of curcumin and curcumin analogues in rheumatology. Int J Rheum Dis. 2015 Jul;18(6):591-3. doi: 10.1111/1756-185X.12753. PubMed PMID: 26301972.

83: Campa M, Ryan C, Menter A. An overview of developing TNF-α targeted therapy for the treatment of psoriasis. Expert Opin Investig Drugs. 2015;24(10):1343-54. doi: 10.1517/13543784.2015.1076793. Epub 2015 Aug 8. Review. PubMed PMID: 26289788.

84: Coradini K, Friedrich RB, Fonseca FN, Vencato MS, Andrade DF, Oliveira CM, Battistel AP, Guterres SS, da Rocha MI, Pohlmann AR, Beck RC. A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies. Eur J Pharm Sci. 2015 Oct 12;78:163-70. doi: 10.1016/j.ejps.2015.07.012. Epub 2015 Jul 20. PubMed PMID: 26206297.

85: Comblain F, Serisier S, Barthelemy N, Balligand M, Henrotin Y. Review of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014. J Vet Pharmacol Ther. 2016 Feb;39(1):1-15. doi: 10.1111/jvp.12251. Epub 2015 Jul 23. Review. PubMed PMID: 26205697.

86: Naz Z, Ahmad FJ. Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation. Int J Nanomedicine. 2015 Jul 3;10:4293-307. doi: 10.2147/IJN.S82788. eCollection 2015. PubMed PMID: 26170665; PubMed Central PMCID: PMC4498720.

87: Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol. 2015 Sep;83:111-24. doi: 10.1016/j.fct.2015.05.022. Epub 2015 Jun 9. Review. PubMed PMID: 26066364.

88: Chen JJ, Dai L, Zhao LX, Zhu X, Cao S, Gao YJ. Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis. Sci Rep. 2015 May 19;5:10278. doi: 10.1038/srep10278. PubMed PMID: 25988362; PubMed Central PMCID: PMC4437313.

89: Yeh CC, Su YH, Lin YJ, Chen PJ, Shi CS, Chen CN, Chang HI. Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis. Drug Des Devel Ther. 2015 Apr 20;9:2285-300. doi: 10.2147/DDDT.S78277. eCollection 2015. PubMed PMID: 25945040; PubMed Central PMCID: PMC4408943.

90: Yang Y, Wu X, Wei Z, Dou Y, Zhao D, Wang T, Bian D, Tong B, Xia Y, Xia Y, Dai Y. Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca(2+)/CaMKII signaling pathways in the small intestine. Pharmacol Res. 2015 May-Jun;95-96:71-81. doi: 10.1016/j.phrs.2015.03.016. Epub 2015 Mar 30. PubMed PMID: 25836921.

91: Comblain F, Sanchez C, Lesponne I, Balligand M, Serisier S, Henrotin Y. Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator’s synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer. PLoS One. 2015 Mar 23;10(3):e0121654. doi: 10.1371/journal.pone.0121654. eCollection 2015. PubMed PMID: 25799427; PubMed Central PMCID: PMC4370821.

92: Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. J Diet Suppl. 2016;13(2):209-20. doi: 10.3109/19390211.2015.1008611. Epub 2015 Feb 17. PubMed PMID: 25688638.

93: Belcaro G, Dugall M, Luzzi R, Ledda A, Pellegrini L, Cesarone MR, Hosoi M, Errichi M. Meriva®+Glucosamine versus Condroitin+Glucosamine in patients with knee osteoarthritis: an observational study. Eur Rev Med Pharmacol Sci. 2014;18(24):3959-63. PubMed PMID: 25555891.

94: Jain SK, Gill MS, Pawar HS, Suresh S. Novel Curcumin Diclofenac Conjugate Enhanced Curcumin Bioavailability and Efficacy in Streptococcal Cell Wall-induced Arthritis. Indian J Pharm Sci. 2014 Sep;76(5):415-22. PubMed PMID: 25425755; PubMed Central PMCID: PMC4243258.

95: Nonose N, Pereira JA, Machado PR, Rodrigues MR, Sato DT, Martinez CA. Oral administration of curcumin (Curcuma longa) can attenuate the neutrophil inflammatory response in zymosan-induced arthritis in rats. Acta Cir Bras. 2014 Nov;29(11):727-34. PubMed PMID: 25424293.

96: Arora R, Kuhad A, Kaur IP, Chopra K. Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur J Pain. 2015 Aug;19(7):940-52. doi: 10.1002/ejp.620. Epub 2014 Nov 17. PubMed PMID: 25400173.

97: Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov;19(6):933-9. doi:
10.1007/s00776-014-0633-0. Epub 2014 Oct 13. PubMed PMID: 25308211; PubMed Central PMCID: PMC4244558.

98: Joe B, Nagaraju A, Gowda LR, Basrur V, Lokesh BR. Mass-spectrometric identification of T-kininogen I/thiostatin as an acute-phase inflammatory protein suppressed by curcumin and capsaicin. PLoS One. 2014 Oct 9;9(10):e107565. doi: 10.1371/journal.pone.0107565. eCollection 2014. PubMed PMID: 25299597; PubMed Central PMCID: PMC4191995.

99: Horcajada MN, Sanchez C, Membrez Scalfo F, Drion P, Comblain F, Taralla S, Donneau AF, Offord EA, Henrotin Y. Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig. Osteoarthritis Cartilage. 2015 Jan;23(1):94-102. doi: 10.1016/j.joca.2014.08.016. Epub 2014 Sep 8. PubMed PMID: 25219641.

100: Sullivan CB, Porter RM, Evans CH, Ritter T, Shaw G, Barry F, Murphy JM. TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathway. Stem Cell Res Ther. 2014 Aug 27;5(4):104. doi: 10.1186/scrt492. PubMed PMID: 25163844; PubMed Central PMCID: PMC4177434.

101: Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A. Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial. Drug Res (Stuttg). 2015 Oct;65(10):521-5. doi: 10.1055/s-0034-1384536. Epub 2014 Jul 22. PubMed PMID: 25050518.

102: Jeengar MK, Shrivastava S, Nair K, Singareddy SR, Putcha UK, Talluri MV, Naidu VG, Sistla R. Improvement of bioavailability and anti-inflammatory potential of curcumin in combination with emu oil. Inflammation. 2014 Dec;37(6):2139-55. doi: 10.1007/s10753-014-9948-4. PubMed PMID: 25028100.

103: Gupta SC, Tyagi AK, Deshmukh-Taskar P, Hinojosa M, Prasad S, Aggarwal BB. Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. Arch Biochem Biophys. 2014 Oct 1;559:91-9. doi: 10.1016/ Epub 2014 Jun 16. Review. PubMed PMID: 24946050.

104: Henrotin Y, Gharbi M, Dierckxsens Y, Priem F, Marty M, Seidel L, Albert A, Heuse E, Bonnet V, Castermans C. Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial. BMC Complement Altern Med. 2014 May 17;14:159. doi: 10.1186/1472-6882-14-159. PubMed PMID: 24886572; PubMed Central PMCID: PMC4032499.

105: Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res. 2014 Nov;28(11):1625-31. doi: 10.1002/ptr.5174. Epub 2014 May 22. PubMed PMID: 24853120.

106: Lee KH, Abas F, Mohamed Alitheen NB, Shaari K, Lajis NH, Israf DA, Syahida A. Chemopreventive effects of a curcumin-like diarylpentanoid [2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro. Int J Rheum Dis. 2015 Jul;18(6):616-27. doi: 10.1111/1756-185X.12341. Epub 2014 May 16. PubMed PMID: 24832356.

107: Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58535. eCollection 2014. PubMed PMID: 24672232; PubMed Central PMCID: PMC3964021.

108: Clutterbuck AL, Allaway D, Harris P, Mobasheri A. Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1β-treated articular cartilage. Version 2. F1000Res. 2013 Jul 4 [revised 2013 Jan 1];2:147. doi: 10.12688/f1000research.2-147.v2. eCollection 2013. PubMed PMID: 24555068; PubMed Central PMCID: PMC3901452.

109: Wada TT, Araki Y, Sato K, Aizaki Y, Yokota K, Kim YT, Oda H, Kurokawa R, Mimura T. Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts. Biochem Biophys Res Commun. 2014 Feb 21;444(4):682-6. doi: 10.1016/j.bbrc.2014.01.195. Epub 2014 Feb 7. PubMed PMID: 24513290.

110: Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai S. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J Nutr Biochem. 2014 Feb;25(2):144-50. doi: 10.1016/j.jnutbio.2013.09.013. Epub 2013 Nov 6. PubMed PMID: 24445038.

111: Madhu CS, Manukumar HM, Basavaraju P. New-vista in finding antioxidant and anti-inflammatory property of crude protein extract from Sauropus androgynus leaf. Acta Sci Pol Technol Aliment. 2014 Oct-Dec;13(4):375-383. doi: 10.17306/J.AFS.2014.4.4. PubMed PMID: 28067479.

112: Buhrmann C, Shayan P, Aggarwal BB, Shakibaei M. Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes. Arthritis Res Ther. 2013;15(6):R202. PubMed PMID: 24283517; PubMed Central PMCID: PMC3979010.

113: Kuncha M, Naidu VG, Sahu BD, Gadepalli SG, Sistla R. Curcumin potentiates the anti-arthritic effect of prednisolone in Freund’s complete adjuvant-induced arthritic rats. J Pharm Pharmacol. 2014 Jan;66(1):133-44. doi: 10.1111/jphp.12156. Epub 2013 Oct 21. PubMed PMID: 24138213.

114: Maruta H. Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity. Phytother Res. 2014 May;28(5):656-72. doi: 10.1002/ptr.5054. Epub 2013 Aug 14. Review. PubMed PMID: 23943274.

115: Asher GN, Spelman K. Clinical utility of curcumin extract. Altern Ther Health Med. 2013 Mar-Apr;19(2):20-2. Review. PubMed PMID: 23594449.

116: Yanase S, Luo Y, Maruta H. PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans. Drug Discov Ther. 2013 Feb;7(1):29-35. PubMed PMID: 23524941.

117: Zheng M, Zhang Q, Joe Y, Lee BH, Ryu DG, Kwon KB, Ryter SW, Chung HT. Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction. Int Immunopharmacol. 2013 Mar;15(3):517-23. doi: 10.1016/j.intimp.2013.02.002. Epub 2013 Feb 15. PubMed PMID: 23415873.

118: Kloesch B, Becker T, Dietersdorfer E, Kiener H, Steiner G. Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes. Int Immunopharmacol. 2013 Feb;15(2):400-5. doi: 10.1016/j.intimp.2013.01.003. Epub 2013 Jan 22. PubMed PMID: 23347846.

119: Liu JF, Hou SM, Tsai CH, Huang CY, Hsu CJ, Tang CH. CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion. Biochim Biophys Acta. 2013 May;1833(5):966-75. doi: 10.1016/j.bbamcr.2012.12.023. Epub 2013 Jan 8. PubMed PMID: 23313051.

120: Shehzad A, Rehman G, Lee YS. Curcumin in inflammatory diseases. Biofactors. 2013 Jan-Feb;39(1):69-77. doi: 10.1002/biof.1066. Epub 2012 Dec 22. Review. PubMed PMID: 23281076.

121: Tsai CH, Chiang YC, Chen HT, Huang PH, Hsu HC, Tang CH. High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation. Biochim Biophys Acta. 2013 Mar;1830(3):2649-58. PubMed PMID: 23274526.

122: Lin YM, Hsu CJ, Liao YY, Chou MC, Tang CH. The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. PLoS One. 2012;7(11):e49999. doi: 10.1371/journal.pone.0049999. Epub 2012 Nov 21. PubMed PMID: 23185512; PubMed Central PMCID: PMC3503714.

123: Huang G, Xu Z, Huang Y, Duan X, Gong W, Zhang Y, Fan J, He F. Curcumin protects against collagen-induced arthritis via suppression of BAFF production. J Clin Immunol. 2013 Apr;33(3):550-7. doi: 10.1007/s10875-012-9839-0. Epub 2012 Nov 27. PubMed PMID: 23184090.

124: Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. Review. PubMed PMID: 23143785; PubMed Central PMCID: PMC3535097.

125: Kumar K, Rai AK. Proniosomal formulation of curcumin having anti-inflammatory and anti-arthritic activity in different experimental animal models. Pharmazie. 2012 Oct;67(10):852-7. PubMed PMID: 23136720.

126: Lian YT, Yang XF, Wang ZH, Yang Y, Yang Y, Shu YW, Cheng LX, Liu K. Curcumin serves as a human kv1.3 blocker to inhibit effector memory T lymphocyte activities. Phytother Res. 2013 Sep;27(9):1321-7. doi: 10.1002/ptr.4863. Epub 2012 Nov 7. PubMed PMID: 23132777.

127: Liu J, Chen S, Lv L, Song L, Guo S, Huang S. Recent progress in studying curcumin and its nano-preparations for cancer therapy. Curr Pharm Des. 2013;19(11):1974-93. Review. PubMed PMID: 23116308.

128: Yang C, Su X, Liu A, Zhang L, Yu A, Xi Y, Zhai G. Advances in clinical study of curcumin. Curr Pharm Des. 2013;19(11):1966-73. Review. PubMed PMID: 23116307.

129: Kumar S, Ahuja V, Sankar MJ, Kumar A, Moss AC. Curcumin for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2012 Oct 17;10:CD008424. doi: 10.1002/14651858.CD008424.pub2. Review. PubMed PMID: 23076948; PubMed Central PMCID: PMC4001731.

130: Shishodia S. Molecular mechanisms of curcumin action: gene expression. Biofactors. 2013 Jan-Feb;39(1):37-55. doi: 10.1002/biof.1041. Epub 2012 Sep 20. Review. PubMed PMID: 22996381.

131: Kumar D, Kumar M, Saravanan C, Singh SK. Curcumin: a potential candidate for matrix metalloproteinase inhibitors. Expert Opin Ther Targets. 2012 Oct;16(10):959-72. doi: 10.1517/14728222.2012.710603. Epub 2012 Aug 23. Review. PubMed PMID: 22913284.

132: Sylvester J, El Mabrouk M, Ahmad R, Chaudry A, Zafarullah M. Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases. Cell Physiol Biochem. 2012;30(3):563-74. doi: 10.1159/000341438. Epub 2012 Jul 23. PubMed PMID: 22832115.

133: Shen CL, Smith BJ, Lo DF, Chyu MC, Dunn DM, Chen CH, Kwun IS. Dietary polyphenols and mechanisms of osteoarthritis. J Nutr Biochem. 2012 Nov;23(11):1367-77. doi: 10.1016/j.jnutbio.2012.04.001. Epub 2012 Jul 23. Review. PubMed PMID: 22832078.

134: Tsou HK, Chen HT, Chang CH, Yang WY, Tang CH. Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts. J Cell Biochem. 2012 Nov;113(11):3509-19. doi: 10.1002/jcb.24227. PubMed PMID: 22711527.

135: Patel MK, Barvaliya MJ, Patel TK. Evaluation of the concomitant use of methotrexate and curcumin on Freund’s complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2012 May;44(3):425; author reply 426. doi: 10.4103/0253-7613.96357. PubMed PMID: 22701264; PubMed Central PMCID: PMC3371477.

136: Huang CY, Chen SY, Tsai HC, Hsu HC, Tang CH. Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. Arthritis Rheum. 2012 Oct;64(10):3344-54. doi: 10.1002/art.34557. PubMed PMID: 22674286.

137: Mobasheri A, Henrotin Y, Biesalski HK, Shakibaei M. Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci. 2012;13(4):4202-32. doi: 10.3390/ijms13044202. Epub 2012 Mar 30. Review. PubMed PMID: 22605974; PubMed Central PMCID: PMC3344210.

138: Colitti M, Gaspardo B, Della Pria A, Scaini C, Stefanon B. Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs. Vet Immunol Immunopathol. 2012 Jun 30;147(3-4):136-46. doi: 10.1016/j.vetimm.2012.04.001. Epub 2012 Apr 26. PubMed PMID: 22591841.

139: Recio MC, Andujar I, Rios JL. Anti-inflammatory agents from plants: progress and potential. Curr Med Chem. 2012;19(14):2088-103. Review. PubMed PMID: 22414101.

140: Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. doi: 10.1002/ptr.4639. Epub 2012 Mar 9. PubMed PMID: 22407780.

141: Kamarudin TA, Othman F, Mohd Ramli ES, Md Isa N, Das S. Protective effect of curcumin on experimentally induced arthritic rats: detailed histopathological study of the joints and white blood cell count. EXCLI J. 2012 May 15;11:226-36. eCollection 2012. PubMed PMID: 27366139; PubMed Central PMCID: PMC4928023.

142: Pinsornsak P, Niempoog S. The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J Med Assoc Thai. 2012 Jan;95 Suppl 1:S51-8. PubMed PMID: 23964444.

143: Khan MA, El-Khatib R, Rainsford KD, Whitehouse MW. Synthesis and anti-inflammatory properties of some aromatic and heterocyclic aromatic curcuminoids. Bioorg Chem. 2012 Feb;40(1):30-8. doi: 10.1016/j.bioorg.2011.11.004. Epub 2011 Nov 25. PubMed PMID: 22172598.

144: Chuan YP, Zeng BY, O’Sullivan B, Thomas R, Middelberg AP. Co-delivery of antigen and a lipophilic anti-inflammatory drug to cells via a tailorable nanocarrier emulsion. J Colloid Interface Sci. 2012 Feb 15;368(1):616-24. doi: 10.1016/j.jcis.2011.11.014. Epub 2011 Nov 22. PubMed PMID: 22153851.

145: Banji D, Pinnapureddy J, Banji OJ, Kumar AR, Reddy KN. Evaluation of the concomitant use of methotrexate and curcumin on Freund’s complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011 Sep;43(5):546-50. doi: 10.4103/0253-7613.84970. PubMed PMID: 22021998; PubMed Central PMCID: PMC3195125.

146: Banji D, Pinnapureddy J, Banji OJ, Saidulu A, Hayath MS. Synergistic activity of curcumin with methotrexate in ameliorating Freund’s Complete Adjuvant induced arthritis with reduced hepatotoxicity in experimental animals. Eur J Pharmacol. 2011 Oct 1;668(1-2):293-8. doi: 10.1016/j.ejphar.2011.06.006. Epub 2011 Jun 16. PubMed PMID: 21693118.
147: Rajasekaran SA. Therapeutic potential of curcumin in gastrointestinal diseases. World J Gastrointest Pathophysiol. 2011 Feb 15;2(1):1-14. doi: 10.4291/wjgp.v2.i1.1. PubMed PMID: 21607160; PubMed Central PMCID: PMC3097964.

148: Shakibaei M, Mobasheri A, Buhrmann C. Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes Nutr. 2011 May;6(2):171-9. doi: 10.1007/s12263-010-0179-5. Epub 2010 May 25. PubMed PMID: 21484156; PubMed Central PMCID: PMC3092909.

149: White B, Judkins DZ. Clinical Inquiry. Does turmeric relieve inflammatory conditions? J Fam Pract. 2011 Mar;60(3):155-6. Review. PubMed PMID: 21369559.

150: Khalifé S, Zafarullah M. Molecular targets of natural health products in arthritis. Arthritis Res Ther. 2011 Feb 3;13(1):102. doi: 10.1186/ar3222. PubMed PMID: 21345249; PubMed Central PMCID: PMC3157637.

151: Olsen NJ. Nutraceuticals for the treatment of osteoarthritis. Minerva Med. 2011 Feb;102(1):33-40. Review. PubMed PMID: 21317847.

152: Guimarães MR, Coimbra LS, de Aquino SG, Spolidorio LC, Kirkwood KL, Rossa C Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res. 2011 Apr;46(2):269-79. doi: 10.1111/j.1600-0765.2010.01342.x. Epub 2011 Feb 8. PubMed PMID: 21306385; PubMed Central PMCID: PMC3086370.

153: Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010 Dec;15(4):337-44. PubMed PMID: 21194249.

154: Henrotin Y, Lambert C, Couchourel D, Ripoll C, Chiotelli E. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products. Osteoarthritis Cartilage. 2011 Jan;19(1):1-21. doi: 10.1016/j.joca.2010.10.017. Epub 2010 Oct 28. Review. PubMed PMID: 21035558.

155: Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010 Jun;52(2 Suppl 1):55-62. PubMed PMID: 20657536.

156: Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. 2011 Mar 1;12(3):332-47. Review. PubMed PMID: 20955148; PubMed Central PMCID: PMC3025067.

157: Buhrmann C, Mobasheri A, Matis U, Shakibaei M. Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther. 2010;12(4):R127. doi: 10.1186/ar3065. Epub 2010 Jul 1. PubMed PMID: 20594343; PubMed Central PMCID: PMC2945017.

158: Wang HM, Zhao YX, Zhang S, Liu GD, Kang WY, Tang HD, Ding JQ, Chen SD. PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. J Alzheimers Dis. 2010;20(4):1189-99. doi: 10.3233/JAD-2010-091336. PubMed PMID: 20413894.

159: Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int Immunopharmacol. 2010 May;10(5):605-10. doi: 10.1016/j.intimp.2010.02.011. Epub 2010 Feb 23. PubMed PMID: 20188213.

160: Kurien BT, D’Souza A, Scofield RH. Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies: a possible therapy to alleviate autoimmune disorders. Mol Nutr Food Res. 2010 Aug;54(8):1202-9. doi: 10.1002/mnfr.200900106. PubMed PMID: 20146265; PubMed Central PMCID: PMC3545698.

161: Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther. 2009;11(6):R165. doi: 10.1186/ar2850. Epub 2009 Nov 4. PubMed PMID: 19889203; PubMed Central PMCID: PMC3003513.

162: Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 2010 Feb;18(2):141-9. doi: 10.1016/j.joca.2009.10.002. Epub 2009 Oct 8. Review. PubMed PMID: 19836480.

163: Mun SH, Kim HS, Kim JW, Ko NY, Kim DK, Lee BY, Kim B, Won HS, Shin HS, Han JW, Lee HY, Kim YM, Choi WS. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway. J Pharmacol Sci. 2009 Sep;111(1):13-21. PubMed PMID: 19763044.

164: Clutterbuck AL, Mobasheri A, Shakibaei M, Allaway D, Harris P. Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann N Y Acad Sci. 2009 Aug;1171:428-35. doi: 10.1111/j.1749-6632.2009.04687.x. PubMed PMID: 19723086.

165: Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53. Review. Erratum in: Altern Med Rev. 2009 Sep;14(3):277. PubMed PMID: 19594223.

166: Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res. 2009 Dec;58(12):899-908. doi: 10.1007/s00011-009-0063-1. Epub 2009 Jul 5. PubMed PMID: 19579007.

167: Kim DK, Kim SJ, Kang SS, Jin EJ. Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells. Exp Mol Med. 2009 Sep 30;41(9):656-64. doi: 10.3858/emm.2009.41.9.072. PubMed PMID: 19478554; PubMed Central PMCID: PMC2753659.

168: Jancinová V, Perecko T, Nosál R, Kostálová D, Bauerová K, Drábiková K. Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition. Eur J Pharmacol. 2009 Jun 10;612(1-3):161-6. doi: 10.1016/j.ejphar.2009.03.080. Epub 2009 Apr 14. PubMed PMID: 19371737.

169: Capini C, Jaturanpinyo M, Chang HI, Mutalik S, McNally A, Street S, Steptoe R, O’Sullivan B, Davies N, Thomas R. Antigen-specific suppression of inflammatory arthritis using liposomes. J Immunol. 2009 Mar 15;182(6):3556-65. doi: 10.4049/jimmunol.0802972. PubMed PMID: 19265134.

170: Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol. 2008 Sep;74(3):654-61. doi: 10.1124/mol.108.046201. Epub 2008 Jun 24. PubMed PMID: 18577686; PubMed Central PMCID: PMC2638506.

171: Chowdhury TT, Salter DM, Bader DL, Lee DA. Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression. Inflamm Res. 2008 Jul;57(7):306-13. doi: 10.1007/s00011-007-7126-y. PubMed PMID:

172: Tong KM, Shieh DC, Chen CP, Tzeng CY, Wang SP, Huang KC, Chiu YC, Fong YC, Tang CH. Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts. Cell Signal. 2008 Aug;20(8):1478-88. doi: 10.1016/j.cellsig.2008.04.003. Epub 2008 Apr 15. PubMed PMID: 18501560.

173: Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008 Apr;114(2):127-49. doi: 10.1080/13813450802033958 . Review. PubMed PMID: 18484280.

174: Toegel S, Wu SQ, Piana C, Unger FM, Wirth M, Goldring MB, Gabor F, Viernstein H. Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. Osteoarthritis Cartilage. 2008 Oct;16(10):1205-12. doi: 10.1016/j.joca.2008.01.013. Epub 2008 Mar 5. PubMed PMID: 18321735.

175: Lev-Ari S, Lichtenberg D, Arber N. Compositions for treatment of cancer and inflammation. Recent Pat Anticancer Drug Discov. 2008 Jan;3(1):55-62. Review. PubMed PMID: 18289124.

176: Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alzheimer’s disease: An overview. Ann Indian Acad Neurol. 2008 Jan;11(1):13-9. doi: 10.4103/0972-2327.40220. PubMed PMID: 19966973; PubMed Central PMCID: PMC2781139.

177: Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007 Nov-Dec;4(6):807-18. Epub 2007 Nov 14. Review. PubMed PMID: 17999464.

178: Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “Curecumin”: from kitchen to clinic. Biochem Pharmacol. 2008 Feb 15;75(4):787-809. Epub 2007 Aug 19. Review. PubMed PMID: 17900536.

179: Kurien BT, Singh A, Matsumoto H, Scofield RH. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol. 2007 Aug;5(4):567-76. PubMed PMID: 17767425.

180: Park C, Moon DO, Choi IW, Choi BT, Nam TJ, Rhu CH, Kwon TK, Lee WH, Kim GY, Choi YH. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. Int J Mol Med. 2007 Sep;20(3):365-72. PubMed PMID: 17671742.

181: Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol. 2007;595:471-80. Review. PubMed PMID: 17569225.

182: Bright JJ. Curcumin and autoimmune disease. Adv Exp Med Biol. 2007;595:425-51. Review. PubMed PMID: 17569223.

183: Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol. 2007;595:127-48. Review. PubMed PMID: 17569208.

184: Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75. Review. PubMed PMID: 17569205.

185: Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007 Jun;7(3):344-51. Epub 2007 May 1. Review. PubMed PMID: 17475558.

186: Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007 May 1;73(9):1434-45. Epub 2007 Jan 7. PubMed PMID: 17291458.

187: Jagetia GC, Aggarwal BB. “Spicing up” of the immune system by curcumin. J Clin Immunol. 2007 Jan;27(1):19-35. Epub 2007 Jan 9. Review. PubMed PMID: 17211725.

188: Gururajan M, Dasu T, Shahidain S, Jennings CD, Robertson DA, Rangnekar VM, Bondada S. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol. 2007 Jan 1;178(1):111-21. PubMed PMID: 17182546.

189: Kurien BT, Scofield RH. Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification–an in vitro study. J Ethnopharmacol. 2007 Mar 21;110(2):368-73. Epub 2006 Oct 13. PubMed PMID: 17116380.

190: Jackson JK, Higo T, Hunter WL, Burt HM. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm Res. 2006 Apr;55(4):168-75. PubMed PMID: 16807698.

191: Tohda C, Nakayama N, Hatanaka F, Komatsu K. Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract. Evid Based Complement Alternat Med. 2006 Jun;3(2):255-60. Epub 2006 Apr 5. PubMed PMID: 16786056; PubMed Central PMCID: PMC1475933.

192: Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM, Timmermann BN. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod. 2006 Mar;69(3):351-5. PubMed PMID: 16562833; PubMed Central PMCID: PMC2533857.

193: Shishodia S, Sethi G, Aggarwal BB. Curcumin: getting back to the roots. Ann N Y Acad Sci. 2005 Nov;1056:206-17. PubMed PMID: 16387689.

194: Cho ML, Jung YO, Moon YM, Min SY, Yoon CH, Lee SH, Park SH, Cho CS, Jue DM, Kim HY. Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways. Immunol Lett. 2006 Mar 15;103(2):159-66. Epub 2005 Nov 16. PubMed PMID: 16368150.

195: Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A. Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann Anat. 2005 Nov;187(5-6):487-97. PubMed PMID: 16320828.

196: Lev-Ari S, Strier L, Kazanov D, Elkayam O, Lichtenberg D, Caspi D, Arber N. Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford). 2006 Feb;45(2):171-7. Epub 2005 Oct 25. PubMed PMID: 16249246.

197: Molnar V, Garai J. Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. Int Immunopharmacol. 2005 May;5(5):849-56. Epub 2005 Jan 27. PubMed PMID: 15778121.

198: Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci. 2004 Dec;1030:434-41. Review. PubMed PMID: 15659827.

199: Min SY, Hwang SY, Jung YO, Jeong J, Park SH, Cho CS, Kim HY, Kim WU. Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes. J Rheumatol. 2004 May;31(5):875-83. PubMed PMID: 15124245.

200: Lin SK, Kok SH, Yeh FT, Kuo MY, Lin CC, Wang CC, Goldring SR, Hong CY. MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factor. Arthritis Rheum. 2004 Mar;50(3):785-93. PubMed PMID: 15022320.

201: Kawasaki H, Komai K, Nakamura M, Yamamoto E, Ouyang Z, Nakashima T, Morisawa T, Hashiramoto A, Shiozawa K, Ishikawa H, Kurosaka M, Shiozawa S. Human wee1 kinase is directly transactivated by and increased in association with c-Fos/AP-1: rheumatoid synovial cells overexpressing these genes go into aberrant mitosis. Oncogene. 2003 Oct 9;22(44):6839-44. PubMed PMID: 14534529.

202: Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M, Zafarullah M. Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp Cell Res. 2003 Aug 1;288(1):208-17. PubMed PMID: 12878172.

203: Banerjee M, Tripathi LM, Srivastava VM, Puri A, Shukla R. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacol Immunotoxicol. 2003 May;25(2):213-24. PubMed PMID: 12784914.

204: Innes JF, Fuller CJ, Grover ER, Kelly AL, Burn JF. Randomised, double-blind, placebo-controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Vet Rec. 2003 Apr 12;152(15):457-60. PubMed PMID: 12723628.

205: Liacini A, Sylvester J, Li WQ, Zafarullah M. Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol. 2002 Apr;21(3):251-62. PubMed PMID: 12009331.

206: Bremner P, Heinrich M. Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol. 2002 Apr;54(4):453-72. Review. PubMed PMID: 11999122.

207: Neff L, Zeisel M, Sibilia J, Schöller-Guinard M, Klein JP, Wachsmann D. NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci. Cell Microbiol. 2001 Oct;3(10):703-12. PubMed PMID: 11580755.

208: Li WQ, Dehnade F, Zafarullah M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol. 2001 Mar 1;166(5):3491-8. PubMed PMID: 11207308.

209: Lodha R, Bagga A. Traditional Indian systems of medicine. Ann Acad Med Singapore. 2000 Jan;29(1):37-41. Review. PubMed PMID: 10748962.

210: Onodera S, Kaneda K, Mizue Y, Koyama Y, Fujinaga M, Nishihira J. Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J Biol Chem. 2000 Jan 7;275(1):444-50. PubMed PMID: 10617637.

211: Kita A, Imano K, Seto Y, Yakuo I, Deguchi T, Nakamura H. Antinociceptive and antidepressant-like profiles of BL-2401, a novel enkephalinase inhibitor, in mice and rats. Jpn J Pharmacol. 1997 Dec;75(4):337-46. PubMed PMID: 9469639.

212: Joe B, Rao UJ, Lokesh BR. Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin. Mol Cell Biochem. 1997 Apr;169(1-2):125-34. PubMed PMID: 9089639.

213: Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res. 1980 Apr;71:632-4. PubMed PMID: 7390600.

214: Srimal RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol. 1973 Jun;25(6):447-52. PubMed PMID: 4146582.

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