May 28, 2022
Live Well Club

Arthritis is a painful condition that affects many seniors, both in Australia and worldwide.

Currently, there are close to a thousand scientific articles on turmeric and its analogues, which have been used successfully in the treatment of arthritis. For some, however, there is difficulty in the absorption of turmeric. Thankfully, there are methods to address this.

Golden Paste

Golden Paste (recipe found here) is the simplest method to aid in the absorption of turmeric in the treatment of your arthritis. This can be incorporated into your food and consumed at the rate of half to one teaspoon per serve.

Healthy Gut

For your body to effectively metabolise the turmeric, you will need a healthy adaptive gut biota, which is achieved by high-fibre natural vegetable intake, eliminating all added sugars and processed foods that have sugar additives. This includes biscuits, cakes, desserts, sauces, and snack foods.

Note, if consumption of turmeric causes diarrhoea, this is indicative of a poor microflora gut population. Diet change is needed to build a healthy adaptive population of microbes in the gastrointestinal system.

Curcumin

Studies have shown the curcumin could effectively alleviate gouty arthritis through inhibiting involved inflammatory mediators. This suggests it to be a promising active ingredient for the prevention and treatment of gouty arthritis.

Curcumin has been found to be a preventive measure to avoid/manage tooth root infection (periodontitis), as well as work as a natural immunosuppressant for rheumatoid arthritis.

Periodontitis is mainly caused by the bacteria Porphyromonas gingivalis forming biofilm and leading to tooth decay. This is a major public health issue and a risk factor for the development of rheumatoid arthritis. Curcumin appears to have efficient anti-bacterial activity against P. Gingivalis infection, and biofilm formation.

Autoimmunity

In addition to antibacterial, antioxidant, and anti-inflammatory action, curcumin exerts unique immunosuppressant properties.

Curcumin is a natural product for the management of both periodontitis and rheumatoid arthritis-related autoreactivity.

When it comes to your health, it is always best to speak with your GP before making any diet or exercise changes. In your next appointment, make sure to enquire about turmeric and how it may help you live a happier and healthier life.

Courtesy of Dr Doug – www.turmericlife.com.au

The information and views contained in this article are those of the author and this publication has not sought to verify them. The contents of this article are not advice; they are general in nature and do not take into account your personal health or circumstances. You should seek professional healthcare advice before taking supplements, additives or anything that affects your health. Australian Over 50s Living & Lifestyle Guide.

1: Li X, Xu DQ, Sun DY, Zhang T, He X, Xiao DM. Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling. J Cell Biochem. 2018 Dec 28.doi: 10.1002/jcb.27969. [Epub ahead of print] PubMed PMID: 30592318.

CONCLUSIONS:
These results indicated that curcumin could effectively ameliorate MSU crystal-induced gouty arthritis through NLRP3 inflammasome mediation via inhibiting NF-κB signaling both in vitro and in vivo, suggesting a promising active ingredient for the prevention and treatment of gouty arthritis. Curcumin was injected intraperitoneally though to shortcut any poor intestinal absorption.
2: Dai Q, Zhou D, Xu L, Song X. Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. Drug Des Devel Ther. 2018 Dec 3;12:4095-4105. doi: 10.2147/DDDT.S175763. eCollection 2018.
PubMed PMID: 30584274; PubMed Central PMCID: PMC6284537.

CONCLUSION:
Our findings show that curcumin alleviates CIA-induced inflammation, synovial hyperplasia, and the other main features involved in the pathogenesis of CIA via the mTOR pathway. These results provide evidence for the anti-arthritic properties of curcumin and corroborate its potential use for the treatment of Reumatoid Arthritis. Dose of curcumin was 200mg/kg though, = 14gms for a human and also the rats were treated with rapamycin which is a standard treatment for RA.
Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. Wikipedia
3: Song X, Zhang M, Dai E, Luo Y. Molecular targets of curcumin in breast cancer (Review). Mol Med Rep. 2018 Nov 19. doi:.3892/mmr.2018.9665. [Epub ahead of print] PubMed PMID: 30483727.

ABSTRACT:
Curcumin (diferuloylmethane), an orange yellow component of turmeric or curry powder, is a polyphenol natural product isolated from the rhizome of Curcuma longa.
For centuries, curcumin has been used in medicinal preparations and as a food colorant.
In recent years, extensive in vitro and in vivo studies have suggested that curcumin possesses activity against
cancer, viral infection, arthritis, amyloid aggregation, oxidation and inflammation.
Curcumin exerts anticancer effects primarily by activating apoptotic pathways in cancer cells and inhibiting pro cancer processes, including inflammation, angiogenesis and metastasis.
Curcumin targets numerous signaling pathways associated with cancer therapy, including pathways mediated by p53, Ras, phosphatidylinositol 3 kinase, protein kinase B, Wnt β catenin and mammalian target of rapamycin. Clinical studies have demonstrated that curcumin alone or combined with other drugs exhibits promising anticancer activity in patients with breast cancer without adverse effects. In the present review, the chemistry and bioavailability of curcumin and its molecular targets in breast cancer are discussed. Future research directions are discussed to further understand this promising natural product.
4: Sun Z, Wei T, Zhou X. Liposomes encapsulated dimethyl curcumin regulates dipeptidyl peptidase I activity, gelatinase release and cell cycle of spleen lymphocytes in-vivo to attenuate collagen induced arthritis in rats. Int Immunopharmacol. 2018 Dec;65:511-521. doi: 10.1016/j.intimp.2018.10.039. Epub 2018 Nov 5. PubMed PMID: 30408628.

ABSTRACT:
Rheumatoid arthritis (RA) is an autoimmune disease and characterized by the excessive cell proliferation, abnormal cell cycle of lymphocytes and synovial cells.
The therapeutic effects of curcumin in active RA patients were reported, but limited by its insolubility and rapid systemic elimination.
Dimethyl curcumin (DiMC) is a metabolically stable analogue of curcum with anti-inflammatory property.
In this study, liposomes encapsulated dimethyl curcumin (Lipo-DiMC) was prepared to improve the bioavailability and metabolic-stability; collagen induced arthritis (CIA) rat model was employed to investigate the effects of Lipo-DiMC treatments during CIA progress.
Physical assessments and routine-blood-test were performed. Fresh spleen lymphocytes were isolated from normal, CIA and Lipo-DiMC-treated CIA rats; flow-cytometry for cell-cycle analysis, western-blotting for intracellular signal pathway protein expressions, gelatin-zymography for matrix-metalloproteases 2/9 (MMP-2/9) and GF-AFC for dipeptidyl-peptidase I (DPPI) activity assay.
Compared with untreated CIA rats, Lipo-DiMC treatments relieved paw-swellings, suppressed the increments of immunocytes numbers and inhibited DPPI and MMP-2/9 over-activity in blood.
Lipo-DiMC adjusted CIA-induced cell cycle dysfunction at G0/G1-phase and S-phase of spleen lymphocytes for CIA rats.
The intracellular expression-trends of P38, P21, Bcl-2, JNK-1 and DPPI of spleen lymphocytes were observed during CIA progress with and without Lipo-DiMC administrations.
Lipo-DiMC exhibited its therapeutic functions by attenuating CIA development in rats, associated with down-regulating CIA-induced lymphocytes numbers, inhibiting over-expressed of DPPI and MMP-2/9, and adjusting cell cycles.
These findings provide a new insight into the mechanism of Lipo-DiMC treatment in CIA rat model and suggest that Lipo-DiMC could be considered as a potential drug for RA treatment.
5: Tasneem S, Liu B, Li B, Choudhary MI, Wang W. Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents. Pharmacol Res. 2018 Nov 3;139:126-140. doi: 10.1016/j.phrs.2018.11.001. [Epub ahead of print] Review. PubMed PMID: 30395947.

ABSTRACT:
Except for an essential step for the pathology of multiple diseases including atherosclerosis and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing novel approaches for pharmacological interventions.
Thus, molecular understanding of inflammation not only revealed the mechanisms of drug action and their biological targets but also has spawned innovative maneuvers to influence multifaceted biological systems, providing new prospects for drug designing and suggesting important new implications for existing clinical medicine.
Meanwhile, modulation of inflammation with the use of medicinal plants proposed an alternate to conventional therapeutic strategies for numerous ailments, particularly when suppression of inflammation is expected.
In modern literature, several species of medicinal plants have been shown substantial anti-inflammatory and immunomodulatory actions including inhibitory effects on suppression of cellular and humoral immunity, lymphocyte activation, and propagation of apoptosis.
Herein, we reviewed the molecular pharmacology of inflammation, chemical components and biological activities of medicinal plants such as, curcumin from Curcuma longa, and epigallocatechin-3-gallate from Camellia sinensis as well as their mechanism of action during inflammation at molecular level.
An extensive review of the literature and electronic databases was conducted, encompassing PubMed, GoogleScholar, ScienceDirect, medlineplus, www.clinicaltrial.gov, www.fda.gov, www.ema.europa.eu, www.drugbank.ca, TrialBulletin.com, www.theplantlist.org, and www.pharmacodia.com for assembling the information.
Additionally, data was attained from books, ethnopharmacological literature, and relevant publications for essential elements of molecular mechanisms, signal transduction networks, transcription factors, complement system, reactive species, and clinical trials are selected for substantial understanding of biochemistry, pathophysiology as well as clinical importance of medicinal plants during inflammatory diseases.

6: Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases. Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Review. PubMed PMID: 30319623; PubMed Central PMCID: PMC6170639.

ABSTRACT:
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases.
The inflammatory molecules and transcription factors, adhesion molecules, AP-1, chemokines, C-reactive protein (CRP), cyclooxygenase (COX)-2, interleukins (ILs), 5-lipooxygenase (5-LOX), matrix metalloproteinases (MMPs), nuclear factor (NF)-kB, signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor (TNF), and vascular endothelial growth factor (VEGF) are molecular links between inflammation and chronic diseases.
Thus, suppression of inflammatory molecules could be potential strategy for the prevention and therapy of chronic diseases.
The currently available drugs against chronic diseases are highly expensive, minimally effective and produce several side effects when taken for long period of time.
The focus of this review is to discuss the potential of nutraceuticals derived from “Mother Nature” such as apigenin, catechins, curcumin, ellagic acid, emodin, epigallocatechin gallate, escin, fisetin, flavopiridol, genistein, isoliquiritigenin, kaempferol, mangostin, morin, myricetin, naringenin, resveratrol, silymarin, vitexin, and xanthohumol in suppression of these inflammatory pathways.
Thus, these nutraceuticals offer potential in preventing or delaying the onset of chronic diseases. We provide evidence for the potential of these nutraceuticals from pre-clinical and clinical studies.
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